Irene Garcia De Melendrez, 77, of Harrisburg, passed away at home surrounded by family on Wednesday, December 24, 2025. Born on October 8, 1948 in La Barca, Mexico, she was the daughter of the late Mauel Garcia and Elena Trujillo. She was the loving wife of the late Jose Carmen Melendrez. She was also preceded in death by her son Eduardo, I; and her siblings Eloisa, Ramiro, and Rodolfo.

Irene was a devoted Catholic and member of St. Francis of Assisi Roman Catholic Church, where prayed the rosary and prayed to Padre Pio and Our Lady of Lourdes. She loved shopping at Boscov’s and Costo, as well as sight-seeing and exploring new places. Most of all, she was devoted to her family. She was a loving wife, mother, grandmother, and great-grandmother who will be deeply missed.

Irene is survived by her children, Irma (Carlos), Carmen (Alfonso), Claudia, Eduardo (Josefina), Maria Magdelena (Armando), Erika (Sergio), Omar (Elizabeth), and Alvaro (Tiffany); her siblings Ignacio, Gonzalo, Eugenio, Patricia, and Manuel; as well as 21 grandchildren, 6 great-grandchildren; and a large extended family of cousins, nieces, and nephews.

Mass of Christian Burial will be celebrated at 11:00 AM on Monday, January 5, 2026 at St. Francis of Assisi Roman Catholic Church, 1439 Market Street, Harrisburg, PA 17103. Burial will be held in Mexico at a later date. A Viewing will take place in the church prior to mass from 10:00-11:00 AM. In lieu of flowers, memorial contributions can be made to St. Francis of Assisi Roman Catholic Church at the address above.